Hereditary Angioedema: A Clinical Review for the Otolaryngologist
نویسندگان
چکیده
منابع مشابه
Hereditary angioedema: a broad review for clinicians.
Hereditary angioedema (HAE) is an autosomal dominant disease that afflicts 1 in 10,000 to 1 in 150,000 persons; HAE has been reported in all races, and no sex predominance has been found. It manifests as recurrent attacks of intense, massive, localized edema without concomitant pruritus, often resulting from one of several known triggers. However, attacks can occur in the absence of any identif...
متن کاملThe genetics of hereditary angioedema: A review
While our understanding of hereditary angioedema (HAE) has evolved gradually since the condition was first described by Sir William Osler in 1888, it has been greatly enhanced in recent decades, particularly since the turn of the millennium, thanks to intensive research efforts, advances in laboratory techniques, increasing clinical observations, and improved understanding of the link between g...
متن کاملClinical review of hereditary angioedema: diagnosis and management.
Hereditary angioedema (HAE) is caused by a deficiency in C1 esterase inhibitor and is characterized by sudden attacks of edema associated with discomfort and pain. The disease places patients at risk for disability and death if left untreated. Symptom severity and frequency can be extremely variable even among affected members of the same family. Attacks are not associated with inflammation or ...
متن کاملHereditary Angioedema
Copyright © 2008 Massachusetts Medical Society. A 19-year-old woman presents to the emergency department with light-headedness, severe abdominal pain, and intractable nausea and vomiting that began 12 hours earlier. The patient reports previous episodes of abdominal pain and swelling of her hands and feet that have been attributed possibly to food allergies, which have recently become more freq...
متن کاملKallikrein Inhibition for Hereditary Angioedema.
Management of hereditary angioedema due to C1 inhibitor deficiency has evolved. During the past 10 years, those affected have progressed from underrecognized disability and premature death, through evidence-based hospital treatment, toward self-administration and independence from unscheduled hospital care. Encouraging results from the use of lanadelumab for the prevention of angioedema associa...
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ژورنال
عنوان ژورنال: Ear, Nose & Throat Journal
سال: 2011
ISSN: 0145-5613,1942-7522
DOI: 10.1177/014556131109000110